One late afternoon, Dante is relaxing in his new yet-to-be-named shop when he is greeted by an unknown man claiming to have an invitation from Dante’s brother, Vergil. The man seems fascinated by the jeweled amulet that Dante wears and flips over Dante’s desk and disappears. After dealing with a surprise demon attack, Dante watches as a gigantic tower breaks through the ground and rises high into the air. Wondering what Vergil, who has been missing for an entire year, is up to, Dante accepts the invitation.
At the same time, a young woman witnesses the tower’s ascendance and makes her own way towards the center of town.
The tower is the Temen-ni-gru; the very same tower that the Legendary Dark Knight Sparda used to seal the doorway between the human world and the demon world almost two thousand years ago. Vergil, Dante’s twin brother, and his cohort, Arkham, have raised the Temen-ni-gru once more to obtain demonic power. Though Vergil and Arkham work together, they both have their own agenda. Vergil is not surprised that the demons sent to Dante’s shop were unable to retrieve the amulet of which Vergil has the other half, a gift from his mother to her sons.
Dante fights his way inside, defeating the tower guardians, and encounters the young woman and her motorcycle. Though she offers a parting shot at Dante, courtesy of the rocket launcher she carries, she seems unconcerned about him though as she leaves, Dante notices that her eyes are the same two colors as Arkhams. “This just keeps getting better and better.” Later, Dante comes upon a mysterious clown calling himself “Jester.” Though he appears to want to help Dante, Jester is also a very annoying individual.
Before reaching the top of the Temen-ni-gru, Dante encounters the young woman again, this time as she is plunging to her death over the tower’s edge. Catching her by her leg, she rewards Dante for saving her life by promptly shooting him in the head…twice. His bad luck with women continuing, Dante leaves her be and continues on his way. The young woman pulls herself to safety and concludes that Dante is a demon as well.
Dante finally reaches the top of the Temen-ni-gru. The brother’s reunion suddenly bursts into a fierce battle just as it has always been with the sons of Sparda. But this time, Vergil emerges the victor impaling Dante into the stone with Dante’s own sword. Vergil takes Dante’s amulet but before he and Arkham can leave, the devil within Dante awakens. But another battle was halted as Arkham intervened saying that for now, they had all that they needed and promptly jumped off the tower with Vergil close behind.
Shaking off the shock of his newly awakened powers, Dante follows his brother over the edge of the tower but as he falls, he is swallowed by another of the Temen-ni-gru’s guardians, Leviathon. Not one to be digested, Dante inflicts enough internal damage to kill the flying demon and send it crashing onto one of the tower’s balconies. Dante cuts his way out of the giant corpse and is face to face with the young woman again. But they don’t get a chance to fight each other before they are both swamped by attacking demons. Amidst all the gunfire, Dante asks the woman what her name is. When she refuses to say, Dante names her “Lady” and leaves to follow Vergil. “Who needed your help anyway?” asks Lady as she reloads her weapons.
Inside, Arkham unseals the final doorway but finds that Vergil is annoyed that he keeps looking back expecting to be followed. “Does that woman really bother you?” scowls Vergil and rams his sword through Arkham’s midsection. Vergil tells Arkham he has become weak. Vergil thought that Arkham sacrificing his own wife to obtain demonic power made him useful but there was no further use for him now that the final door was opened. Vergil proceeds into the tower leaving Arkham to die. Shortly after, Dante comes upon Arkham’s body and Lady is incensed at the thought that Dante had killed Arkham and not her something that Dante neither confirms nor denies and runs after Vergil. But Arkham is not dead and with his final breath tells Lady, aka his daughter Mary, that he was possessed and tricked by Vergil and that she must stop him.
Inside the main chamber, Vergil spills his blood on the ground attempting to open the doorway to the demon world but is quickly frustrated when nothing happens. Vergil wonders if more blood is needed and is once again confronted by his little brother and the two battle again. The sons of Sparda fight an exhausting battle just as Lady appears determined to kill Vergil but is stopped by Jester. But Jester was not who he appeared to be and was in fact, Arkham. Arkham had tricked them all into coming here and revealed he needed both Vergil’s and Dante’s blood to open the door to the demon world. Sparda had sacrificed two things to seal the doorway: his own demonic blood and the blood of a human priestess. But as he had no priestess, the blood of the priestess’s decadent would do just fine and overpowering Lady, he stabbed her in the leg with the bayonet attachment of her rocket launcher. With the blood offering fulfilled, the Temen-ni-gru came to life, its internal mechanisms spinning into place. The floor beneath them cracked and enveloped a weakened Vergil allowing Arkham to escape.
As the tower ceased to shake, Lady leaves Dante to settle her own family scores but meets up with him again as she nears the top of the tower. Determined to settle things her way and without the help of a demon, Lady engages Dante in battle but is quickly defeated. Dante makes her see the truth; she is not strong enough to face what is ahead. “Quite frankly,” said Dante, “At first, I didn’t give a damn. But because of you, I know what’s important now. I know what I have to do.” And borrowing Lady’s rocket launcher, the Kalina Ann, Dante set out for the top of the tower after Arkham and the demon world.
Combining the two amulets, Arkham claimed the Force Edge, the sword Sparda had left behind when he sealed the door between worlds. With the power of the Legendary Dark Knight, Arkham became a huge, gelatinous mass. Dante alone was not strong enough to defeat him but then Vergil appeared. Only the combined powers of the sons of Sparda could defeat Arkham and so they did. Arkham was expelled from the demon world but the Force Edge and the amulets fell deeper into the rift and both Vergil and Dante went after them.
Wounded and bitter at having grasped true demonic power only to lose it, Arkham found himself back on Temen-ni-gru and staring down the barrel of Lady’s gun. He died with a single shot and Lady wept despite herself, her mother finally avenged.
Atop a great waterfall, the sons of Sparda fought one last battle. But with the amulets split apart, the door to the human world was closing. Vergil, having lost to Dante, opted to stay in the demon world and plunged over the side of the waterfall into the darkness below.
Dante returned to the human world and returned the rocket launcher to Lady. The single tear Dante shed for his brother was enough to convince Lady that there was a human side to Dante after all and the two formed a partnership to hunt demons wherever they appeared. Dante rebuilt his shop and even decided upon a name for the place. “Wanna know the name?”
Devil May Cry.