Hell Vanguard

The god of death who manages dead souls. He is feared by even inhabitants of the netherworld for his wicked nature and fighting prowess. A deadly sand-based demon.

First appearance: Mission 2
Strategy: Refer to boss strategies.

Enigma

Basically created from a stone statue. Given life via some unusual high level magic incantation. This six-legged demon targets foes from afar with his magical bow.

First appearance: Mission 3
Strategy: Avoid and attack. These 'level-up' as you proceed into the game. They start by shooting blue arrows. Later they shoot red arrows. After their final level-up, they shoot red arrows and evade very quickly from you. When shooting red arrows, they will not stop charging even when you hit them, so facing them head on as they charge can be risky. However, multiple-hit moves like Cerberus' Revolver and Beowulf's Lunar Phase are capable of breaking the arrows and earning you stylish points at the same time. The safest way, however, is to throw them off their feet by shooting with Kalina Ann or Spiral.

Gigapede

Giant creature that made its way into the Human world through a rift in the time-space fabric. Relentlessly strikes down foes with a high voltage attack.

First appearance: Mission 4
Strategy: Refer to boss strategies for mission 4. For Mission 8 inside Leviathan, keep running away from it until it tries to bite you, then double jump away and continue running. With Vergil, use Trick Up. If you wish to kill it, attack it when it is 'stuck' around a bend. Sword Dance for Dante and Aerial Rave for Vergil are recommended.

Blood-Goyle

Blood mixed with magically enchanted stone gave birth to this wretched beast. Multiplies whenever hit by close ranged attacks. Its defense mechanism is weak to modern-day weapons.

First appearance: Mission 5
Strategy: DO NOT slash them with your melee weapons when they're alive and flying. If you happen to do so, they'll split into two and multiply. Shoot them continuously until they turn back into stone, then slash the stone until it shatters. Note that they can also multiply without getting slashed. To prevent that from happening, shoot them into stone before they split.

Arachne

Once the soul of a human female, the soul transformed when it reached the outer crust of the netherworld. Uses her tightly spun spider webbing to ensnare her victims.

First appearance: Mission 9
Strategy: These are quick to move around considering their size. Keep attacking them until they parry you. Once parried, jump away to avoid their claw attack. They also do charge attacks, so jump away to avoid. When they climb the walls, chances are they're going to shoot a web that'll bind you. Run far away to avoid, but if you get caught, either activate Devil Trigger (Dante will break free immediately) or keep smashing all buttons quickly to break free. With Vergil, spam Spiral Swords as you attack with his melee weapons.

Dullahan

The possessed husk of a knight's suit of armor. Its adamantine shell makes it virtually impervious to frontal attack. Its only weak spot being its hindquarters.

First appearance: Mission 10
Strategy: Follow up behind them and attack their backs only. Helm Breaker (vertical slash) is highly recommended. With Vergil, use Yamato's Aerial Rave. In Vergil's mode where they appear again without floating, wait till they charge at you with their spinning shield, get away and around their back, then slash until it shatters.

Soul Eater

Spiritual remnants of the rage of murdered demons have pooled together to create this beast. This creature paralyzes its prey before feasting upon its soul.

First appearance: Mission 11
Strategy: These appear only when you face your backs at them. Deliberately face your backs at them, and once they appear to charge at you, shoot madly. Shooting will slow down their charge but once they get close to you, roll away and continue shooting. They have short lives and should die in a number shots, or if you use Kalina Ann, it should die in 1 shot. If they grab and hang you in the air, activate Devil Trigger or smash all buttons quickly to break free. With Vergil, face your back at them, lock on to them, jump (and keep jumping), and shoot as you jump. Unlike Dante, Vergil is capable of shooting backwards, so you will hit them.

The Fallen

A demon who fell from grace for lying and deceiving its victims. Her beautiful wings close to form an invincible shield. Her open belly is her only weakness.

First appearance: Mission 15
Strategy: First, you have to remove their protective wings. One advice - don't jump too much. They fly all over the place but don't bother chasing them down too much. They will come to you eventually. Once they get down to your level, keep slashing them with the Triangle button (keep left analog neutral). Don't be too worried about getting slashed cause' the moment you hit them they will stop attacking (except for when they swing their swords). They swing their long swords around very often, so once again do not jump about too much. Due to their height, as long as you stay low, their swords will not hit you so get right by and just keep attacking. The only times you NEED to jump away is when they thrust their sword, or throw their sword at you from the air to cause an explosion. Note that they do recover their wings. With Vergil, abuse Aerial Rave, although you will have to be careful not to get hit when they swing their swords.

Abyss

Lives at the deepest level of the netherworld. During times of war, this high ranking demon knows only victory. His magic-imbued sickle has ended many a hero's life.

First appearance: Mission 17
Strategy: Avoid and attack. Be careul, they will always flip back immediately to slash you if you throw them back with thrust moves like Stinger/Straight.